| Product description: |
NAC: N-Acetyl-L-Cysteine: Glutathione precursor and antioxidant with many clinical applications.
- N-Acetyl-L-Cysteine (NAC) is precursor of the tripeptide glutathione – a critical antioxidant, with roles in xenobiotic detoxification and amino acid metabolism. Glutathione depletion is characteristic of many conditions of impaired health (Curr Opin Clin Nutr Metab Care 1999;2:487-92).
- N-Acetyl-L-Cysteine (NAC) acts as a mucolytic agent and thus assists normal respiratory function. By acting as a glutathione precursor, NAC helps maintain normal immune, liver and cardiovascular function (Altern Med Rev 1998;3:114-27).
- N-Acetyl-L-Cysteine (NAC) treatment attenuated the transmigration of mononuclear cells thereby lessening neuroinflammatory disease in animal study. NAC treatment may be of therapeutic value in multiple sclerosis (MS) against the inflammatory disease process associated with the infiltration of activated mononuclear cells into the central nervous system (CNS) (J Autoimmune Diseases 2005;2:4).
- Multiple sclerosis (MS) is a chronic demyelinating disease marked by focal destruction of myelin, resulting in the loss of oligodendrocytes and axons accompanied by an inflammatory disease process (Bar-Or A, Oliveira EM, Anderson DE, Hafler DA: Molecular pathogenesis of multiple sclerosis J Neuroimmunol 1999;100:252-259. Markovic-Plese S, McFarland HF: Immunopathogenesis of the multiple sclerosis lesion Curr Neurol Neurosci Rep 2001;1:257-262. Hemmer B, Archelos JJ, Hartung HP: New concepts in the immunopathogenesis of multiple sclerosis Nat Rev Neurosci 2002;3:291-301.).
- Oral administration of the oxidant scavenger NAC was found to attenuate experimental autoimmune encephalomyelitis (EAE) clinical disease (Lehmann D, Karussis D, Misrachi-Koll R, Shezen E, Ovadia H, Abramsky O: Oral administration of the oxidant-scavenger N-acetyl-L-cysteine inhibits acute experimental autoimmune encephalomyelitis J Neuroimmunol 1994;50:35-42). Experimental autoimmune encephalomyelitis (EAE) is an animal study clinical model for multiple sclerosis.
These studies were designed to elucidate the mechanism of observed therapeutic efficacy of NAC against EAE. Taken together these results suggest NAC may be of therapeutic value for cell-mediated autoimmune diseases such as multiple sclerosis.
- N-acetylcysteine (NAC) enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals (J Appl Physiol 2004;97:1477-1485).
- N-Acetyl-L-Cysteine (NAC) is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. NAC protects cells against death induced by exposure to noxious stimuli and against programmed cell death (apoptosis) associated with exposure to inadequate amounts of trophic factors (Mayer M, Noble M.: Ludwig Institute for Cancer Research, London, UK Proc Natl Acad Sci USA 1994;91:7496-500).
Natural sources, hypoallergenic. |
Karuna 8111 NAC: N-Acetyl-L-Cysteine: Glutathione Precursor 500mg Capsules
