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P.T.I.: Botanical and nutritional factors for pain, trauma and inflammation.
- Niacinamide has been associated with relaxing effects on mental function in animal studies (Nature 1979;278:563-5).
- Vitamin B3, niacinamide, has a long history of clinical investigation for its effects on improving joint function (J Int Acad Prev Med 1983;Winter:5-25.).
- A recent double-blind trial found niacinamide safe and effective for chronic joint discomfort (Inflamm Res 1996;45:330-34).
- B vitamins have been shown to improve the response of spinal syndromes to therapy and help prevent relapses of spinal pain (Klin Wochenschr 1990;68:107-20, Ann NY Acad Sci 1990;585:54-62).
- Clinical trials have found vitamin B6 supplements helpful for diverse conditions, such as reducing urinary oxalates that may disturb normal kidney function (Int Urol Nephrol 1988;20:353-9), stabilizing premenstrual physiology (Br J Obstet Gynaecol 1990;97:847-52), and restoring normal peripheral nerve function (J Occup Environ Med 1997;39:949-59).
- Anemias can result from inadequate dietary levels of Vitamin B6 (pyridoxine) (Baillieres Clin Haematol 1994;7:851-79).
- Calcium and magnesium are essential nutrients having well-recognized effects on neuromuscular function, although clinical studies of these effects are lacking, experimental information suggest that magnesium has a special role in opposing neuromuscular hyperexcitability, as its insufficiency can lead to muscle cramping, nervous excitability, agitation, irritability, restlessness, anxiety and anxious depression.
- Magnesium participates in the regulation of vascular tone and reactivity, acts as a mild calcium channel blocker, and influences the effects of serotonin and other neurotransmitters, as well as platelet function and inflammatory mechanisms (Persp Biol Med 1988;31:526-557).
- Magnesium supplementation helps increase days without head discomfort according to several controlled clinical studies (Headache 1991;31:298-301, Fortschr Med 1994;112:328-330, Cephalalgia 1996;16:257-263).
- Magnesium is important for normal vascular function and supports healthy blood pressure (Hypertension 1998;32:260-5.) and optimal leg circulation (Vasa 1985;14:285-8).
- The magnesium component, normally found in high levels in the brain, participates in maintaining the equilibrium of the central nervous system and promoting healthy lipid metabolism.
- Bromelain is a proteolytic enzyme that can modify prostaglandins (Med Hypoth 1980;6:99-104) and augment the action of natural tissue proteases at the site of injuries (Hiroshima J Med Sci 1975;24:185-193). The resolution of the inflammatory process requires the degradation of inflammatory proteins, fibrin and cell debris in order to restore normal circulation and facilitate tissue repair (Phys Med Rehab 1987;1:523-536).
- Administered orally on an empty stomach, bromelain is absorbed into the bloodstream in amounts effective for the resolution of inflammation (Am J Physiol 1997;273:G139-46, Jpn J Pharmacol 1972;22:519-34)
- The consensus of medical opinion suggests that orally-administered bromelain exerts a salutary effect on recovery and healing in cases of inflammation, injuries and tissue traumas of various kinds, including post-operative problems (Altern Med Rev 1996;1:243-57, Hiroshima J Med Sci 1975;24:185-193).
- Bromelain, taken with meals, acts as a protease, enhancing the release of short peptides and amino acids from food proteins.
- Valerian's active compounds, including valepotriates and valerenic acid, have been shown to effectively potentiate GABA receptor function in the central nervous system (J Pharm Pharmacol 1999;51:505-12).
- Research suggests that the valerenic acid content in Valeriana officinalis interacts in vitro with GABA (gamma-amino-butyric acid) receptors, a critical site for sedation in the brain.
- Valerian root has been shown in clinical studies to reduce sleep latency and promote sleep stages 3 and 4. (Pharmacol Biochem Behav 1982;17:65-71; Planta Med 1985;51:144-8).
- Valerian may improve the ability of humans to cope with mental stress (Pharmacopsychiatry 1988;21:447-8).
- Valerian is a source of valepotriates and valerenic acids, which calm the CNS and relax muscles.
- Valerian has proven to be non-addictive and does not contribute to a 'hung-over' morning feeling following use (Pharmacopsychiatry 1999;32:235-41).
- Clinical research has documented that valerian/passion flower combinations may help stabilize mood and relieve nervous tension in humans (Quart Rev Nat Med 1994;Fall:221-4).
- Valerian and passion flower are principal ingredients of numerous herbal sedative compounds in the U.K. and Europe. They have been used empirically for centuries as mild sedatives and provide an antispasmodic tension relief.
- Passion flower contains flavonoid compounds shown to have relaxing and anti-anxiety effects (Zeitschrift Phytother 1995;16:115-26).
- Valerian and willow bark are principal ingredients of numerous herbal sedative compounds in the U.K. and Europe. They have been used empirically for centuries as mild sedatives and provide an antispasmodic tension relief.
- Willow bark is a natural source of salicylates and other compounds possessing analgesic, anti-inflammatory and antioxidant effects (J Agric Food Chem 1999;47:3954-62; Planta Med 1990;56:660; The Merck Index 1996, 1432).
- Willow bark provides naturally-occurring salicylates, which inhibit the catabolism of tryptophan in the liver and increase the level of free tryptophan in the blood. These actions enhance the delivery of tryptophan to the brain and increase synthesis of serotonin, which is required for normal mood.
- Standardized willow bark extracts have been shown to have significant analgesic effects for patients with either osteoarthritis (Z Rheumatol 2000;59:314-20) or low back pain (Am J Med 2000;109-9-14).
- Willow bark has been judged to have fewer side effects than acetylsalicylic acid (aspirin) (German Commission E 1998, 230).
- Black cohosh has improved mood and sleep in women entering menopause (Planta Medica 1991;57:420-4.)
Natural sources, hypoallergenic. |
Karuna 9113 P.T.I.: Pain/Trauma/Inflammation Vitamun Mineral Enzyme Herbal Complex Capsules
